Mathematical modelling of the atherosclerotic plaque formation

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The atherosclerotic plaque.

Atherosclerosis is the most frequent cause of ischemic heart disease and cerebrovascular disorders. The condition is the leading cause of death in Western societies. At the core of this condition is the atherosclerotic plaque. It is within the structure of this lesion that multiple biochemical and cellular processes interact influencing its vulnerability to rupture and as a result acute ischemi...

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Mathematical modelling of atheroma plaque formation and development in coronary arteries.

Atherosclerosis is a vascular disease caused by inflammation of the arterial wall, which results in the accumulation of low-density lipoprotein (LDL) cholesterol, monocytes, macrophages and fat-laden foam cells at the place of the inflammation. This process is commonly referred to as plaque formation. The evolution of the atherosclerosis disease, and in particular the influence of wall shear st...

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Antagonism of RANTES receptors reduces atherosclerotic plaque formation in mice.

Increasing evidence supports the involvement of inflammation in the early phases of atherogenesis. Recruitment of leukocytes within the vascular wall, controlled by chemokines, is an essential process in the development of this common disease. In this study, we report that blocking a chemokine pathway in vivo with the CC chemokine antagonist Met-RANTES reduces the progression of atherosclerosis...

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ژورنال

عنوان ژورنال: ESAIM: Proceedings

سال: 2009

ISSN: 1270-900X

DOI: 10.1051/proc/2009036